What mechanism does meloxicam work through?

What mechanism does meloxicam work through?

• A. COX-2
• B. COX-1
• C. 5-LOX
• D. MMP inhibitors

Answer: (A)

Meloxicam works by inhibiting cyclooxygenase enzymes, mainly COX-2. By blocking COX-2, it reduces synthesis of prostaglandins such as PGE2 that fuel inflammation, pain, and fever. It’s described as preferential COX-2 inhibition because it affects COX-2 more than COX-1, aiming to lessen inflammation while potentially reducing some COX-1–related GI effects. The other options don’t describe meloxicam’s action: 5-LOX is part of the leukotriene pathway, and MMP inhibitors target matrix metalloproteinases, neither of which is the primary mechanism of meloxicam.

Meloxicam works by inhibiting cyclooxygenase enzymes, mainly COX-2. By blocking COX-2, it reduces synthesis of prostaglandins such as PGE2 that fuel inflammation, pain, and fever. It’s described as preferential COX-2 inhibition because it affects COX-2 more than COX-1, aiming to lessen inflammation while potentially reducing some COX-1–related GI effects. The other options don’t describe meloxicam’s action: 5-LOX is part of the leukotriene pathway, and MMP inhibitors target matrix metalloproteinases, neither of which is the primary mechanism of meloxicam.